Pharmaceutical Tamoxifen , Nolvadex For Tumor · Metastatic Breast Cancer Cas No. 54965-24-1
|Place of Origin:||Shanghai|
Payment & Shipping Terms:
|Minimum Order Quantity:||10 vials|
|Packaging Details:||Plastic Tube / Vial|
|Delivery Time:||3-5 working days|
|Payment Terms:||L/C, D/A, D/P, T/T, Western Union, MoneyGram|
|Supply Ability:||50000 kits/month|
|Type:||Pharmaceutical Intermediates||Cas No.:||57773-63-4|
|Purity:||99%||Grade Standard:||Medicine Grade|
|Product Name:||Triptorellin||Appearance:||White Powder|
|Sample:||Free||Storage:||2-8 Degree Centigrade|
|Specification:||99%,2mg 5mg 10mg Per Vial||Assay:||99%|
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Cas 57773-63-4 Pharmaceutical Peptide Triptorellin For Prostate Cancer
Normal Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.
The first administration of triptorelin is followed by a transient surge of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol,and testosterone. The time, peak and decline of testosterone in the body varies depending on the dose administered. This initial surge is often responsible for worsening of prostate cancer symptoms such as urethral or bladder outlet obstruction, bone pain, spinal cord injury and hematuria in the early stages. A sustained decrease in FSH and LH, and significant reduction of testicular steroidogenesis is usually seen 2-4 weeks post-initiation of therapy. This result is a reduction of serum testosterone to levels which are typically seen in surgically castrated men. Ultimately, tissues and functions that require these hormones become inactive. The effects of triptorelin can usually be reversed once the drug is discontinued.
Mechanism of action
Triptorelin is a synthetic agonist analog of gonadotropin releasing hormone (GnRH). Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone.
Triptorelin is a man-made form of a hormone that regulates many processes in the body. The Trelstar brand of triptorelin is used in men to treat the symptoms of prostate cancer. Trelstar treats only the symptoms of prostate cancer and does not treat the cancer itself.
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