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Clomifene Citrate CAS 50-41-9 for Ovulation-Inducing Fertility Medications for Treating Infertility in Women
Clomiphene Citrate treatment
Clomiphene is a long trusted oral medication relied upon for its safety, effectiveness and relatively low cost. Clomiphene is used to treat absent or irregular menstrual cycles (ovulation induction), to address a condition called luteal phase defect by increasing progesterone secretion during the second half of the cycle and to make menstrual cycle lengths more predictable, thus improving the timing of intercourse or artificial insemination. Clomiphene may also be used to enhance ovulation in women who are already ovulating (ovulation augmentation).
How does Clomiphene Citrate work?
Clomiphene triggers the brain's pituitary gland to secrete an increased amount of follicle stimulating hormone (FSH) and LH (luteinizing hormone). This action stimulates the growth of the ovarian follicle and thus initiates ovulation.
During a normal menstrual cycle only one egg is ovulated. The use of clomiphene often causes the ovaries to produce two or three eggs per cycle. Clomiphene is taken orally for 5 days and is active only during the month it is taken.
Clomiphene citrate treatment success rates
Of women who are anovulatory (unable to produce an egg each month), approximately 70% will ovulate when treated with clomiphene; and conception rates consistent with a patient's age should be achieved. Women less than 35 can achieve pregnancy rates of 20-25% per month as long as there are no other significant factors present. Older patients may not achieve these rates as their declining egg quality will become a factor. We stress that success rates are highly individual and depend on a number of factors. The best thing to do is have a thorough discussion with one's RE physician to gain a better understanding of the likelihood of success with this or any treatment plan.
There are alternate fertility treatments for those who do not become pregnant with clomiphene therapy. If 3-6 full clomiphene cycles do not result in a pregnancy, other methods of ovulation induction can be recommended. For older patients, gonadotropins and intrauterine insemination may be recommended. For younger patients, in whom the risk of multiple gestations may be too high with gonadotropins and IUI, In Vitro Fertilization may be the next best step that will be recommended.
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