Muscle Growth Sarms Liquid , Selective Androgen Receptor Modulator YK11 For Bodybuilding
|Place of Origin:||China|
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|Minimum Order Quantity:||10bottles|
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|Chemical Name:||Ibutamoren||Other Name:||MK-677|
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Sarms bodybuilding Injectable liquid Ibutamoren/MK-677/MK-0677/L-163,191
Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.
Ibutamoren has been shown to sustain activation of the GH–IGF-1 axis and to increase lean body mass with no change in total fat mass or visceral fat. It is under investigation as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising potential therapy for the treatment of frailty in the elderly. As of June 2017, ibutamoren is in the preclinical stage of development for growth hormone deficiency.
However, it has been used experimentally by some in the bodybuilding community. Since it chemically mimics the hormone ghrelin, it functions as a neuropeptide in the central nervous system and crosses the blood-brain-barrier.According to some recent research and discussion, there is a concern that its particularly longer half-life might over-stimulate the ghrelin receptors in the brain and lead to some harmful mental side effects.
In the body, MK-677 binds to ghrelin receptors on the surfaces of cells. This triggers a series of chain reactions including increased secretion of several hormones such as growth hormone (GH) and insulin-like growth factor (IGF-1).
These chain reactions are normally triggered by the action of ghrelin, a peptide hormone primarily released by endocrine cells in the intestines and stomach (1). Ghrelin has various physiological effects such as regulation of appetite (2) and adipose tissue (3), as well as of carbohydrate and energy metabolism (4). Recent studies have also demonstrated its role in cognitive function (5-6).
By mimicking ghrelin, MK-677 thus produces significant physiological benefits:
it boosts muscle growth and strength, by increasing lean body mass (bigger muscles, increased muscle mass, prevention of loss of muscle during weight loss, etc) (7-10), without adding fat mass.
it combats the muscle-wasting typically seen in older people or those temporarily incapacitated (with hip fractures, for example (11).
it boosts bone density and renewal (by increasing levels of osteocalcin) (12).
it improves sleep quality and duration (13). The rises in levels of certain hormones (in particular growth hormone and prolactin) appear to increase the duration of stage 4 sleep (the deepest of the sleep cycle) as well as that of rapid eye movement (REM), part of paradoxical sleep (14).
it combats cellular ageing , primarily by compensating for decreased levels of growth hormone.
it has potential nootropic effects
it promotes faster wound-healing and recovery (15-16) as well as increased tolerance to exercise (17-18).
it increases lipolysis (fat breakdown) (19).
it reduces nitrogenous waste (20).
it lowers blood levels of LDL-cholesterol.
These potential effects are the result of Ibutamoren’s principal action of directly increasing circulating levels of IGF-1, a peptide hormone responsible for boosting protein synthesis and promoting overall tissue growth.
Clinical trials are continuing in order to identify any potential side effects, with a view to potentially authorising its sale for human consumption. Studies conducted so far have demonstrated slight increases in blood pressure, glycated haemoglobin and appetite (21). They have also shown that were it to be authorised for human consumption, it would be contraindicated for those with a history of congestive heart failure, especially elderly individuals. In any case, monitoring blood parameters would be essential, and it would only be possible to recommend those products with rigorously-controlled purity,
However, its physiological effects and therapeutic potential mean that certain groups of people may be interested in monitoring developments in its research:
those seeking improved sports performance and greater tolerance to exercise.
those looking to boost their muscle mass and strength
those recovering from physical injury
those deficient in growth hormone
those who’ve suffered muscle wasting or bone loss
those who want to slow down the ageing process.