Steroids Raw Powder Leucovorin Calcium CAS 1492-18-8 For Methotrexate , Trimethoprim , Pyrimethamine

Product Details:
Place of Origin: Shanghai
Brand Name: Filter
Certification: USP32
Model Number: 1492-18-8
Payment & Shipping Terms:
Minimum Order Quantity: Negotiable
Price: negotiable
Packaging Details: Foil bag
Delivery Time: 1 working days
Payment Terms: L/C, D/A, D/P, T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 100000 kg/ Month

Detail Information

Purity: 99% Grade Standard: Medicine Grade
Appearance: White Powder Color: White
Shelf Life: 2 Years Specification: 99%
Application: Medicine Raw Material Test Method: HPLC
Grade: Phamaceutical Grade Form: Powder
Package: 1roll/ Bag Or As Customized
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Product Description

Steroids Raw Powder Leucovorin Calcium CAS 1492-18-8 for Methotrexate, Trimethoprim, Pyrimethamine

 

An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Check for active clinical trials using this agent.

 

 

As folate analogs, leucovorin and levoleucovorin are both used to counteract the toxic effects of folic acid antagonists, such as methotrexate, which act by inhibiting the enzyme dihydrofolate reductase (DHFR). They are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Injectable forms are also indicated for use in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible and for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Folic acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted when high-dose methotrexate is used for cancer therapy. As methotrexate functions as a DHFR inhibitor to prevent DNA synthesis in rapidly dividing cells, it also prevents the formation of DHF and THF. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects associated with methotrexate therapy. As levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF), they are able to bypass DHFR reduction and act as a cellular replacement for the co-factor THF, thereby preventing these toxic side effects.

 

 

How to use Leucovorin Calcium?
Take this medication by mouth with or without food, usually every 6 hours or once daily or as directed by your doctor.

Dosage is based on your medical condition and response to treatment. Doses above 25 milligrams are not recommended.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if you are unable to take this medication because of nausea/vomiting. You may need to be switched to the injection form of this medication.

 

Steroids Raw Powder Leucovorin Calcium CAS 1492-18-8 For Methotrexate , Trimethoprim , Pyrimethamine 0

 

Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitate you track the express


FAQ
1.How about parcel delivery success rate ?
Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time?

Normally, our min.order quantity is 50g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend?

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship by TNT or FedEx.

 

Steroids Raw Powder Leucovorin Calcium CAS 1492-18-8 For Methotrexate , Trimethoprim , Pyrimethamine 1

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