Product Description
T′amoxifen Citrate 54965-24-1 N`Olvadex Powder for Anti-Estrogen
Description:
| Product name |
Tamoxi Citrate Nolvad |
| Test |
Analysis Standard |
Results |
| Characteristics |
White crystalline powder |
conforms |
| Assay |
99 ~ 101.0% |
99.51% |
| Loss on drying |
≤0.5% |
0.24% |
| Identification |
IR,UV conform |
conforms |
| Residue on ignition |
≤0.2% |
0.06% |
| Iron |
≤0.005% |
0.0016% |
| Heavy metals |
≤0.001% |
0.0006% |
| Related substances |
Total:≤1.0% |
0.37% |
| Individual:≤0.5% |
0.17% |
| E-isomer |
≤0.3% |
0.20% |
| Organic volatile impurities |
conform |
conform |
| Conclusion |
This batch is complies with USP 30. |
|
Synonym:
tamoxifeni citras, Zitazonium
Foreign brand name:
Apo-Tamox, Clonoxifen, Dignotamoxi, Ebefen, Emblon, Estroxyn, Fentamox, Genox, Gen-Tamoxifen, Jenoxifen, Kessar, Ledertam, Lesporene, Nolgen, Noltam, Nolvadex-D, Nourytam, Novofen, Novo-Tamoxifen, Oestrifen, Oncotam, PMS-Tamoxifen, Soltamox, Tamax, Tamaxin, Tamifen, Tamizam, Tamofen, Tamoxasta, Zemide
Chemical structure:
1.(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate
2.(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
Indication:
Treatment of female surname with recurrent metastatic adenocarcinoma.
Used as an adjuvant treatment for breast cancer metastasis after surgery to prevent recurrence.
Description:
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC. Check for active clinical trials using this agent.
Uses:
For the treatment of advanced, recurrent breast and ovarian cancer
A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. It is also being studied in the treatment of other types of cancer. Tamoxifen citrate blocks the effects of the hormone estrogen in breast tissue, which may help keep breast cancer cells from growing. It is a type of selective estrogen receptor modulator (SERM). Tamoxifen is the active ingredient of tamoxifen citrate.
Peptide List:
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